ChemicalBook CAS DataBase List 2-PHENYLETHYL PHENYL ETHER

2-PHENYLETHYL PHENYL ETHER synthesis

14synthesis methods

Product Name:2-PHENYLETHYL PHENYL ETHER
CAS Number:40515-89-7
Molecular formula:C14H14O
Molecular Weight:198.26

103-63-9 Synthesis

103-63-9
506 suppliers
$9.00/10g

108-95-2 Synthesis

108-95-2
708 suppliers
$14.00/25g

40515-89-7
78 suppliers
$10.00/1g

Yield: 60%

Reaction Conditions:

Stage #1:phenol with potassium hydroxide in ethanol at 45; for 0.166667 h;
Stage #2:1-phenyl-2-bromoethane in ethanol for 24 h;Reflux;

Steps:

1-(phenethyloxy)benzene
A solution of phenol (10.16 g, 108.09 mmol), KOH (3.027 g, 54.05 mmol) in ethanol (3.4 mL) was stirring at 45 °C for 10 minutes. To the reaction mixture 1-(2-bromoethyl)benzene (10 g, 54.05 mmol) was added, and the mixture was heated at reflux for 24 h. The mixture was concentrated in vacuum and the residue was dissolve in CH2Cl2. The organic layer was washed with aqueous 2N NaOH and H2O, dried (MgSO4) and the filtrate was concentrated to dryness. The crude product was purified by column chromatography on silica gel (hexane) to yield 1-(phenethyloxy)benzene (6.4 g, 32.32 mmol, 60%).

References:

Patil, Nikhil D.;Yan, Ning [Tetrahedron Letters,2016,vol. 57,# 27-28,p. 3024 - 3028] Location in patent:supporting information

4249-72-3 Synthesis