2-[(quinazolin-4-yl)amino]ethan-1-ol synthesis
- Product Name:2-[(quinazolin-4-yl)amino]ethan-1-ol
- CAS Number:5423-59-6
- Molecular formula:C10H11N3O
- Molecular Weight:189.21
5190-68-1
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Yield:-
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20;
Steps:
1 Example 1 This example illustrates the preparation method of compound I-A7-D1-1
Add 2-((quinazolin-4-yl)amino)ethanol to 4-chloroquinazoline (20 mmol) and potassium carbonate (40 mmol) in N,N-dimethylformamide (20 mL) at room temperature with stirring In the solution, 2-aminoethanol (30 mmol) was added dropwise and stirred for 10-20 h until the reaction was complete.The reactant was poured into ice water, extracted with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure to obtain 3.19 g of the title compound.
References:
CN113754636,2021,A Location in patent:Paragraph 0117; 0118; 0119
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