4-Hydroxyquinazoline synthesis
- Product Name:4-Hydroxyquinazoline
- CAS Number:491-36-1
- Molecular formula:C8H6N2O
- Molecular Weight:146.15
118-48-9
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122-51-0
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491-36-1
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Yield:491-36-1 85%
Reaction Conditions:
with ammonium acetate;Thiamine hydrochloride in ethanol for 4 h;Reflux;
Steps:
Quinazolin-4(3H)-one (7)
A mixture of isatoic anhydride 1 (5 mmol), triethyl orthoformate 6 (6 mmol), ammonium acetate 3 (7.5 mmol), VB1 (0.15 mmol, 3 mol %) in EtOH (5 mL) was heated to reflux for 4 h. After completion of the reaction (TLC), the solid was filtered off, washed with EtOH and recrystallized from EtOH (5 mL) to yield pure product 7.
References:
Chen, Yijia;Shan, Weiguang;Hu, Lihong;Lei, Min [Tetrahedron Letters,2012,vol. 53,# 44,p. 5923 - 5925,3] Location in patent:supporting information
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28144-70-9
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491-36-1
325 suppliers
$5.00/25mg
118-48-9
405 suppliers
$5.00/5 g
491-36-1
325 suppliers
$5.00/25mg