ChemicalBook CAS DataBase List 2-THIENYLTRIMETHYLSILANE

2-THIENYLTRIMETHYLSILANE synthesis

8synthesis methods

Product Name:2-THIENYLTRIMETHYLSILANE
CAS Number:18245-28-8
Molecular formula:C7H12SSi
Molecular Weight:156.32

2-Trimethylsilylthiophene can be used as an organic reagent, is synthesized by 2-Bromothiophene and Chlorotrimethylsilane in Inert atmosphere.

188290-36-0 Synthesis

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1450-14-2
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18245-28-8
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17906-71-7
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Yield:-

Reaction Conditions:

with potassium ethoxide in tetrahydrofuran at 45; for 24 h;Overall yield = 70 %Spectr.;

Steps:

6.4 Silylation of Thiophene
[0130] Experiments conducted with thiophene under Condition A, resulted in a 1:4 ratio of mono:bis silylated product, in 70% combined yield, as determined by 1H NMR. ‘H NMR for mono (300 MHz, CDC13), 3: 7.59 (m, 1H), 7.29-7.24 (m, 1H), 7.19 (dd, J = 4.6, 3.3 Hz, 1H), 0.34 (s, 9H). ‘HNMRforbis (300 JVII-Tz, CDC13), 6: 7.34 (s, 2H), 0.34 (s, 18H).

References:

CALIFORNIA INSTITUTE OF TECHNOLOGY;TOUTOV, Anton;LIU, Wenbo;GRUBBS, Robert, H.;STOLTZ, Brian, M.;BETZ, Kerry;SCHUMAN, David, P. WO2016/100606, 2016, A1 Location in patent:Paragraph 0130

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188290-36-0 Synthesis

188290-36-0
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