methyl 2-((methoxycarbonyl)methyl)-5-methoxybenzoate synthesis
- Product Name:methyl 2-((methoxycarbonyl)methyl)-5-methoxybenzoate
- CAS Number:255376-41-1
- Molecular formula:C12H14O5
- Molecular Weight:238.24
Yield:255376-41-1 98.3%
Reaction Conditions:
with potassium carbonate in acetone; for 4 h;Reflux;
Steps:
14.Procedures for the preparation of methyl5-methoxy-2-(2-methoxy-2-oxoethyl)benzoate(14)
9.0 g (0.039 mol) Compound 13 was dissolved in 100 ml dry acetone, 18 g (0.12 mol) anhydrous potassium carbonate and 4 ml(0.044 mol) dimethyl sulfate were added, refluxed for 4 h, cooled, filtered. Thefilter cake was washed with acetone, the filtrate was concentrated underreduced pressure to give a yellow oil 14 9.4 g,in yield of 98.3%.
References:
Zhao, Qian;Xu, Xi;Xie, Zhouling;Liu, Xiao;You, Qidong;Guo, Qinglong;Zhong, Yi;Li, Zhiyu [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 3,p. 1068 - 1072] Location in patent:supporting information
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