Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine
71701-92-3

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine synthesis

3synthesis methods
A mixture of 3-bromo-5-(trifluoromethyl)pyridin-2-ol (37.75g, 0.16 mol) and phosphorus(lll) oxychloride (POCI3; 75 mL) is stirred at 1000C for 5 hours. After cooling to room temperature, the mixture is poured into ice-water and extracted with CH2CI2 twice. The combined organic layer is washed with NaHCO3 aq., brine, dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture is purified by flash column chromatography to give 3-bromo-2-chloro-5-trifluoromethylpyridine (31.90 g, 79 % yield) as a white solid.
76041-73-1 Synthesis
3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine

76041-73-1
136 suppliers
$9.00/1g

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine

71701-92-3
156 suppliers
$5.00/1g

-

Yield: 79%

Reaction Conditions:

Stage #1:3-bromo-5-(trifluoromethyl)pyridin-2-ol with trichlorophosphate at 100; for 5 h;
Stage #2: with sodium hydrogencarbonate in dichloromethane;water

Steps:

B.2
A mixture of 3-bromo-5-(trifluoromethyl)pyridin-2-ol (37.75g, 0.16 mol) and phosphorus(lll) oxychloride (POCI3; 75 mL) is stirred at 1000C for 5 hours. After cooling to room temperature, the mixture is poured into ice-water, and extracted with CH2CI2 twice. The combined organic layer is washed with NaHCO3 aq., brine, dried over MgSO4, filtered and concentrated in vacuo. The crude mixture is purified by flash column chromatography to give 3-bromo-2-chloro-5-trifluoromethylpyridine (31.90 g, 79 % yield) as a white solid. 1H-NMR (400MHz, CDCI3), δ (ppm): 8.17 (m, 1H), 8.62 (d, 1 H).

References:

Location in patent:Page/Page column 75

79456-30-7 Synthesis
2-Amino-3-bromo-5-(trifluoromethyl)-pyridine

79456-30-7
129 suppliers
$6.00/250mg

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine

71701-92-3
156 suppliers
$5.00/1g

References
76041-73-1 Synthesis
3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine

76041-73-1
136 suppliers
$9.00/1g

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine

71701-92-3
156 suppliers
$5.00/1g

References

3-Bromo-2-chloro-5-(trifluoromethyl)pyridine Related Search:

Pyridine 2,4,6-Collidine 2-(Trifluoromethyl)pyridine 2-Chloro-5-(chloromethyl)pyridine 2,6-Lutidine Picoxystrobin 3-BroMo-5-chloro-thieno[3,2-b]pyridine 3-Bromo-5-(trifluoromethyl)pyridine 2-Bromo-3-chloro-5-(trifluoromethyl)pyridine