ethyl cyclopent-3-ene-1-carboxylate synthesis
- Product Name:ethyl cyclopent-3-ene-1-carboxylate
- CAS Number:21622-01-5
- Molecular formula:C8H12O2
- Molecular Weight:140.18
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Yield: 89.42%
Reaction Conditions:
with thionyl chloride at 5 - 20; for 1.5 h;
Steps:
1
Example 1 Preparation of ethyl-3-cyclopentene-1-carboxylate (5) A solution of 3-cyclopentene-1-carboxylic acid (500 g, 4.45 mole) in ethanol (500 mL) was stirred at 5-10° C. Then thionyl chloride (257.59 g, 2.16 mole) was added in a drop wise manner for 1 hr. After complete addition was over, the reaction mixture was stirred at room temperature for 30 min. The reaction mixture was poured into the water (1000 mL) and extracted with ethyl acetate (2*250 mL). The ethyl acetate layer was washed with 10% sodium carbonate solution (500 mL), with water (2*500 mL) and concentrated to give ethyl-3-cyclopentene-1-carboxylate (5). Yield: 558 g, 89.42%.
References:
Tarur, Venkatasubramanian Radhakrishnan;Sathe, Dhananjay Govind;Bhise, Nandu Baban;Sawant, Kamlesh Digambar;Naik, Tushar Anil;Srivastav, Neeraj;Deore, Raviraj Bhatu US2008/275241, 2008, A1 Location in patent:Page/Page column 10
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