4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE synthesis
- Product Name:4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE
- CAS Number:757251-39-1
- Molecular formula:C13H12FN3O2
- Molecular Weight:261.25
1209459-88-0
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399-95-1
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$14.00/5g
757251-39-1
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Yield:757251-39-1 97.5%
Reaction Conditions:
with N-benzyl-N,N,N-triethylammonium chloride;potassium iodide;sodium hydroxide in water at 30 - 70; for 2 h;Reagent/catalyst;
Steps:
4 Preparation of Compound III
Add 4.71g of 4-amino-3-fluorophenol, 4.13g of sodium hydroxide, 32.11g of potassium iodide, 22.78g of triethylbenzylammonium chloride, 500ml of water to the reaction flask, and heat to 30 ° C to stir and dissolve. When the temperature reaches At 70 ° C, 21.61 g of compound III was added dropwise, and the reaction was stirred for 2 h. After completion of the reaction, the mixture was cooled, washed with a 2% aqueous sodium hydroxide solution, and the mixture was separated. The organic layer was recrystallized from ethanol to give compound IV 25.48 g, product yield 97.5%, purity 99.96%.
References:
CN108329260,2018,A Location in patent:Paragraph 0014; 0025; 0028; 0031-0034
394-41-2
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220000-87-3
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757251-39-1
248 suppliers
$11.00/250mg
![Phenol, 4-[(1,2-dimethylpropylidene)amino]-3-fluoro-](/CAS/20180808/GIF/1338722-53-4.gif)
1338722-53-4
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220000-87-3
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757251-39-1
248 suppliers
$11.00/250mg
1338722-54-5
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220000-87-3
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757251-39-1
248 suppliers
$11.00/250mg
882167-77-3
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$9.00/1g
399-95-1
435 suppliers
$14.00/5g
757251-39-1
248 suppliers
$11.00/250mg