ChemicalBook CAS DataBase List 4-Amino-3-fluorophenol

4-Amino-3-fluorophenol synthesis

11synthesis methods

Product Name:4-Amino-3-fluorophenol
CAS Number:399-95-1
Molecular formula:C6H6FNO
Molecular Weight:127.12

Using p-nitrophenol as raw material, after catalytic hydrogenation, a sulfonation reaction is performed first, and then a fluorine substitution reaction is performed to substitute the fluorine at the 3-position. Afterwards, a desulfonation reaction was carried out, and the target product 4-Amino-3-fluorophenol was obtained through extraction.

394-41-2
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399-95-1
394 suppliers
$14.00/5g

Yield:399-95-1 100%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in tetrahydrofuran;ethanol at 20; for 4.5 h;

Steps:

107

To a solution of 3-fluoro-4-nitrophenol (20 g) in ethanol (200 ml)-tetrahydrofuran (125 ml) was added 10% palladium carbon (6.0 g), followed by stirring under a hydrogen atmosphere at room temperature for 4.5 hrs. The mixture was filtered to remove the catalyst, which was washed with ethanol. The filtrate was concentrated under a reduced pressure to provide the titled compound (16.1 g, 100%) as a pale yellow solid. ¹H-NMR Spectrum (DMSO-d₆) δ (ppm): 4.38 (2H, m), 6.34 (1H, m), 6.43 (1H, m), 6.59 (1H, dd, J=8.4, 10.4 Hz), 8.78 (1H, s).

References:

US2005/277652,2005,A1 Location in patent:Page/Page column 72-73

1493-27-2
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$5.00/10g

399-95-1
394 suppliers
$14.00/5g

References

103842-00-8
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399-95-1
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References

7784-21-6
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144-55-8 Synthesis

144-55-8
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1493-27-2
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399-95-1
394 suppliers
$14.00/5g

References

18266-53-0
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$11.00/1g

399-95-1
394 suppliers
$14.00/5g

References

4-Amino-3-fluorophenol Related Search:

3-Aminopyridine Glycine 2-Aminophenol 6-Aminocaproic acid 4-Fluorophenol Acetaminophen Tris(hydroxymethyl)aminomethane 4-Aminophenol 3-Aminophenol 3-Fluorophenol