ChemicalBook CAS DataBase List 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE synthesis

4synthesis methods

Product Name:4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE
CAS Number:287930-73-8
Molecular formula:C11H13NO3
Molecular Weight:207.23

298-12-4 Synthesis

298-12-4
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104-63-2 Synthesis

104-63-2
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287930-73-8
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$6.00/5g

Yield:287930-73-8 91%

Reaction Conditions:

in tetrahydrofuranReflux;

Steps:

1
To a 250ml reaction flask was added 50% glyoxylic acid (67ml, 0.61mol) and tetrahydrofuran (130ml), heated to reflux, was added dropwise N- benzyl ethanolamine (41.5g, 0.27mol) in tetrahydrofuran (20ml) solution, to the reaction complete, the tetrahydrofuran was evaporated, water (170ml), cooled with stirring, to precipitate a solid, ice-water bath was stirred for 30 minutes, filtered and washed with ice water, drying in a yellowish solid, i.e. compounds of formula VII (51.8g, 91%), mp132 ~ 136 .

References:

Jiangsu Hansoh Pharmaceutical Ltd.;Xu, Shiwei;Yuan, Fuping CN103030668, 2016, B Location in patent:Paragraph 0031-0033

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