ChemicalBook CAS DataBase List (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine

(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine synthesis

5synthesis methods

Product Name:(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine
CAS Number:327623-37-0
Molecular formula:C20H18F7NO2
Molecular Weight:437.35

2H-1,4-Oxazine, 2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-

934540-47-3
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(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine

327623-37-0
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2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine

171338-27-5
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$80.00/1mg

Yield:-

Reaction Conditions:

with hydrogen;5% palladium over charcoal in methanol at 30; for 3 h;

Steps:

24

EXAMPLE 24: PREPARATION OF THE COMPOUND OF FORMULA IIIa 16 g of the compound of Formula IVa obtained from Example 23 , 16 g of 5% palladium on carbon, and 160 ml of methanol were charged into a clean and dry hydrogenation vessel. Dry hydrogen gas of pressure 3.0 kg/cm² was passed into the reaction suspension for a period of 3 hours at about 30 ⁰C. After the EPO completion of the reaction, reaction suspension was filtered through celite and was washed with 80 ml of methanol. The resultant filtrate was distilled completely under vacuum to afford a crude syrup (Formula IIIa). 100 ml of acetonitrile was charged to the residue, left overnight and the separated solid was filtered to obtain 5 g of the title compound.Specific optical rotation: [α]_D=0.00° ( C= 1% MeOH);Purity by RS HPLC: A₈B₇ at retention time (RT) 17.1 minutes: 87.39%, A₇B₈ at retention time (RT) 19.2 minutes: 8.23%.

References:

WO2007/44829,2007,A2 Location in patent:Page/Page column 43