4-Benzyloxybromobenzene synthesis
- Product Name:4-Benzyloxybromobenzene
- CAS Number:6793-92-6
- Molecular formula:C13H11BrO
- Molecular Weight:263.13
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Yield: 100%
Reaction Conditions:
with potassium carbonate in acetonitrile for 6 h;
Steps:
34.A
Intermediate 34; (+/-)-3-(4-Hydroxy-phenyl)-2-methyl-propionic acid methyl ester; Step A; 4-Bromophenol (3.55 g, 20.5 mmol) is dissolved in acetonitrile (50 mL). Powdered potassium carbonate (3.86 g, 27.9 mmol) is added while stirring, followed by dropwise addition of benzyl bromide (2.4 mL, 20.2 mmol). The mixture is vigorously stirred under nitrogen for 6 h. Filtration and concentration yielded 4-benzyloxy-bromobenzene 32 (5.52 g, quant.) as an oil that slowly solidified: 1H-NMR (400 MHz, CDCl3) δ = 7.37, (m, 7H), 6.87 (m, 2H), 5.07 (s, 2H).
References:
IRM LLC WO2007/56497, 2007, A1 Location in patent:Page/Page column 32
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