(4-bromophenyl)-2-pyridyl ketone synthesis
- Product Name:(4-bromophenyl)-2-pyridyl ketone
- CAS Number:18453-32-2
- Molecular formula:C12H8BrNO
- Molecular Weight:262.1
5029-67-4
299 suppliers
$6.00/1g
586-76-5
491 suppliers
$10.00/1g
18453-32-2
22 suppliers
$271.00/250mg
Yield:18453-32-2 80%
Reaction Conditions:
Stage #1: 4-Bromobenzoic acidwith isopropylmagnesium bromide in tetrahydrofuran;2-methyltetrahydrofuran at 20;Inert atmosphere;Cooling with ice;
Stage #2: 2-iodopyridine in tetrahydrofuran;2-methyltetrahydrofuran;Inert atmosphere;
Stage #3: with TurboGrignard in tetrahydrofuran;2-methyltetrahydrofuran at 20; for 2 h;Inert atmosphere;
References:
Demkiw, Krystyna;Araki, Hirofumi;Elliott, Eric L.;Franklin, Christopher L.;Fukuzumi, Yoonjoo;Hicks, Frederick;Hosoi, Kazushi;Hukui, Tadashi;Ishimaru, Yoichiro;O'Brien, Erin;Omori, Yoshimasa;Mineno, Masahiro;Mizufune, Hideya;Sawada, Naotaka;Sawai, Yasuhiro;Zhu, Lei [Journal of Organic Chemistry,2016,vol. 81,# 8,p. 3447 - 3456]
100-70-9
422 suppliers
$13.00/25g
106-37-6
488 suppliers
$9.00/5g
18453-32-2
22 suppliers
$271.00/250mg
109-04-6
539 suppliers
$6.00/25g
18453-32-2
22 suppliers
$271.00/250mg
1122-91-4
702 suppliers
$9.00/10g
18453-32-2
22 suppliers
$271.00/250mg