4-Ethoxy-2-pyridinecarboxylic acid ethyl ester synthesis
- Product Name:4-Ethoxy-2-pyridinecarboxylic acid ethyl ester
- CAS Number:71777-70-3
- Molecular formula:C10H13NO3
- Molecular Weight:195.22
5470-22-4
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64-17-5
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$10.00/50g
71777-70-3
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$63.00/100mg
Yield:71777-70-3 93%
Reaction Conditions:
sulfuric acid for 48 h;Heating / reflux;
Steps:
6
A solution of 4-chloropicolinic acid (3.0 g, 19.04 mmol) in EtOH (100 mL) was mixed with H^SO4 (cone, 5 ml_) and was stirred at reflux for 48 hours. The reaction mixture was cooled to room temperature and neutralized with NaOH (1 N) to adjust pH = 8~9. The mixture was extract with dichloromethane (3x100 mL) and concentration to afforded ethyl 4-ethoxypicolinate (3.44 g, 93%).
References:
WO2007/16525,2007,A2 Location in patent:Page/Page column 54
19235-89-3
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64-17-5
756 suppliers
$10.00/50g
71777-70-3
46 suppliers
$63.00/100mg
53750-66-6
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64-17-5
756 suppliers
$10.00/50g
71777-70-3
46 suppliers
$63.00/100mg