ChemicalBook CAS DataBase List 4-Methoxyisophthalic acid

4-Methoxyisophthalic acid synthesis

14synthesis methods

Product Name:4-Methoxyisophthalic acid
CAS Number:2206-43-1
Molecular formula:C9H8O5
Molecular Weight:196.16

22955-73-3 Synthesis

22955-73-3
47 suppliers
$190.80/5g

2206-43-1
109 suppliers
$8.00/5g

Yield:2206-43-1 90%

Reaction Conditions:

with water;sodium hydroxide at 80; for 2 h;

Steps:

3 Example 3 Synthesis of 4-methoxyisophthalic acid (3)

At room temperature, 2g (8.92mmol) of dimethyl 4-methoxyisophthalate was added to 15mL of sodium hydroxide aqueous solutionMedium (1.07g sodium hydroxide, 26.76mmol).Heat to 80C and stir. As the reaction proceeds, 4-methoxyisophthalic acidThe dimethyl ester is gradually dissolved in the aqueous sodium hydroxide solution.After 2 hours of reaction, the hydrolysis was complete.After the solution is cooled to room temperature, stir vigorouslyNext, adjust the pH of the solution with concentrated hydrochloric acid.When the pH of the solution reaches 1-2, a large amount of white solid precipitates out, so stop adding hydrochloric acid.Keep stirring for 30Minutes later, filter, wash the filter cake with ice water until the washing liquid is weakly acidic, and vacuum dry the filter cake to obtain 1.57 g of white solid (yield90%),

References:

CN112159347,2021,A Location in patent:Paragraph 0027; 0034-0035

20628-07-3 Synthesis