4-Methylbenzamide oxime synthesis
- Product Name:4-Methylbenzamide oxime
- CAS Number:19227-13-5
- Molecular formula:C8H10N2O
- Molecular Weight:150.18
104-85-8
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121-44-8
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19227-13-5
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Yield: 62%
Reaction Conditions:
with hydroxylamine hydrochloride in aqueous EtOH;ethanol
Steps:
2 2.1 Synthesis of p-Tolylamidoxime (2a)
2.1 Synthesis of p-Tolylamidoxime (2a) Hydroxylamine hydrochloride (1.3 g, 18 mmol) was added to a solution of Et3 N (2.5 mL, 18 mmol) in 50% aqueous EtOH (4.2 mL). After 30 minutes p-methylbenzonitrile (1.7 g, 15 mmol) in EtOH (40 mL) was added and the mixture was allowed to reflux for 8 hours. The mixture was cooled to room temperature and poured into water (100 mL). The aqueous solution was decanted, concentrated to half of its original volume. Upon standing the product crystallized to afford 2a as a white solid (1.7 g, 62 %); m/z (M+H)+ 150.2 (C8 H110 N2 O).
References:
CombiChem, Inc. US6107313, 2000, A
104-85-8
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$11.00/25g
19227-13-5
106 suppliers
$10.00/250mg
104-87-0
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19227-13-5
106 suppliers
$10.00/250mg
104-85-8
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75-05-8
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19227-13-5
106 suppliers
$10.00/250mg
104-85-8
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$11.00/25g
19227-13-5
106 suppliers
$10.00/250mg
619-55-6
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