ChemicalBook CAS DataBase List 4-Nitrophenyl isocyanate

4-Nitrophenyl isocyanate synthesis

14synthesis methods

Product Name:4-Nitrophenyl isocyanate
CAS Number:100-28-7
Molecular formula:C7H4N2O3
Molecular Weight:164.12

32315-10-9 Synthesis

32315-10-9
411 suppliers
$10.00/1g

100-01-6
10 suppliers
$11.19/25G

100-28-7
7 suppliers
$32.79/5g

Yield:100-28-7 100%

Reaction Conditions:

with triethylamine in dichloromethane at 25;

Steps:

1 Synthesis of Compound 1
To the reaction flask were added 138 g (1 mol) of p-nitroaniline, 110 g (lmol) of triethylamine, 2000 ml of dichloromethane, A solution of 296 g (lmol) of triphosgene in 2000 ml of methylene chloride was added dropwise at 25 ° C at room temperature, and the reaction was continued at that temperature for 3 to 5 hours. The HPLC reaction was followed until the nitroaniline reaction was complete, 3000 ml of water was added, the layers were separated, the organic phase was concentrated and distilled under reduced pressure to give 164 g of the compound 1 was obtained in a molar yield of 100%.

References:

Jiangnan University;Song, Xiaoqing CN104387383, 2016, B Location in patent:Paragraph 0035; 0040; 0041

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