6-CHLORO-3-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE synthesis
- Product Name:6-CHLORO-3-(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE
- CAS Number:40971-95-7
- Molecular formula:C6H2ClF3N4
- Molecular Weight:222.56
17284-97-8
198 suppliers
$8.00/1g
401-67-2
164 suppliers
$19.00/5g
40971-95-7
48 suppliers
$55.00/50mg
Yield:40971-95-7 600 mg
Reaction Conditions:
in toluene at 110; for 16 h;
Steps:
16 Synthesis of A-19:
To a suspension of A-2 (500.00 mg, 3.46 mmol) in toluene (10 mL) was added (2,2-difluoroacetyl) 2,2-difluoroacetate (662.43 mg, 3.81 mmol) slowly. The reaction mixture was stirred at 110 C for 16 hours. The reaction mixture was concentrated, diluted with sat.NaHC03 (30 mL), and the product was extracted with EtOAc (20 mL x 2). The combined organic phase was washed with brine (10 mL), dried over Na2S04, filtered and concentrated to give A-19 (600.00 mg, 2.91 mmol) as a solid. LCMS R, = 0.33 min using Method B, MS ESI calcd. for C6H4C1F2N4 [M+H]+ 205.0, found 204.9.
References:
WO2018/98499,2018,A1 Location in patent:Page/Page column 132
17284-97-8
198 suppliers
$8.00/1g
76-05-1
715 suppliers
$9.00/1g
40971-95-7
48 suppliers
$55.00/50mg
17284-97-8
198 suppliers
$8.00/1g
407-25-0
472 suppliers
$9.00/1g
40971-95-7
48 suppliers
$55.00/50mg