5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE synthesis
- Product Name:5-AMINO-1-PROPYL-1H-IMIDAZOLE-4-CARBOXAMIDE
- CAS Number:61507-88-8
- Molecular formula:C7H12N4O
- Molecular Weight:168.2
107-10-8
372 suppliers
$10.00/20mg
6719-21-7
119 suppliers
$35.00/500mg
149-73-5
547 suppliers
$12.00/5g
61507-88-8
9 suppliers
$220.00/1g
Yield:61507-88-8 61%
Reaction Conditions:
in acetonitrile;
Steps:
2 5-Amino-1-n-propylimidazole-4-carboxamide
PREPARATION 2 5-Amino-1-n-propylimidazole-4-carboxamide A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallized from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C7 H12 N4 O requires C,49.98; H,7.19; N,33.31%.
References:
US5734053,1998,A
107-10-8
372 suppliers
$10.00/20mg
122-51-0
506 suppliers
$10.00/5ml
6719-21-7
119 suppliers
$35.00/500mg
61507-88-8
9 suppliers
$220.00/1g
