1H-1,2,4-Triazole-3-carboxylicacid,1-methyl-,methylester(9CI) synthesis
- Product Name:1H-1,2,4-Triazole-3-carboxylicacid,1-methyl-,methylester(9CI)
- CAS Number:57031-66-0
- Molecular formula:C5H7N3O2
- Molecular Weight:141.13
4928-87-4
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$9.00/100mg
77-78-1
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$22.00/25g
57031-66-0
71 suppliers
$22.00/250mg
Yield:57031-66-0 85.6%
Reaction Conditions:
with potassium carbonate in acetone at 40; for 4 h;Inert atmosphere;
Steps:
5 Example 5
Under the protection of nitrogen, 1,2,4-triazole-3-carboxylic acid (28.3g, 0.25mol), dimethyl sulfate (78.8g, 0.625mol), potassium carbonate (96.6g, 0.7mol) and acetone Put 200mL into the reaction flask, warm up to 40°C for 4 hours, cool to room temperature, filter, rinse the filter cake with acetone, concentrate the filtrate to no flow, add ethyl acetate to dissolve, wash with water to pH=7-8, organic The phase was concentrated and recrystallized from ethanol to obtain 30.2 g of methyl 1-methyl-1H-1,2,4-triazole-3-carboxylate with a yield of 85.6% and HPLC 99.6%.
References:
CN113321622,2021,A Location in patent:Paragraph 0041-0043
4928-88-5
358 suppliers
$5.00/5g
74-88-4
339 suppliers
$15.00/10g
57031-66-0
71 suppliers
$22.00/250mg
4928-87-4
180 suppliers
$9.00/100mg
616-38-6
655 suppliers
$5.00/5G
57031-66-0
71 suppliers
$22.00/250mg