1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid,ethylester synthesis
- Product Name:1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid,ethylester
- CAS Number:849069-32-5
- Molecular formula:C9H9N3O2
- Molecular Weight:191.19
849069-30-3
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849069-32-5
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$495.00/1g
Yield:849069-32-5 49%
Reaction Conditions:
with 1-methyl-pyrrolidin-2-one;hydrazine hydrate monohydrate at 0 - 80; for 0.333333 h;
Steps:
1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid ethyl ester (QY-9-18):
QY-9-10 (2.87g, 14.6mmol) was added to the 100ml round-bottomed flask, dissolved and stirred after adding 25ml N-methylpyrrolidone, and hydrazine hydrate (0.87g, 17.5mmol) was slowly added dropwise under ice bath conditions to react The solution was kept at 0 °C and stirred for 20 min, gradually returned to room temperature, and then heated to 80 °C and stirred overnight. LC-MS monitored the complete consumption of the reactant, added distilled water, filtered through a membrane filter and separated and purified by a C18 reversed-phase chromatographic column (water: acetonitrile = 0-80%) to obtain 1.37 g of a yellow-red solid with a yield of 49%.
References:
WO2022/57787,2022,A1 Location in patent:Page/Page column 37
64-17-5
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![1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)](/CAS/GIF/116855-08-4.gif)
116855-08-4
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849069-32-5
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$495.00/1g
372-48-5
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849069-32-5
16 suppliers
$495.00/1g