7-(4-METHYLPHENYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL synthesis
- Product Name:7-(4-METHYLPHENYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-OL
- CAS Number:865546-60-7
- Molecular formula:C19H15N3O
- Molecular Weight:301.34
64-18-6
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Yield:865546-60-7 78%
Reaction Conditions:
Stage #1: formic acid;2-amino-1-(4-methylphenyl)-4-phenyl-1H-pyrrole-3-carbonitrile for 5 h;Reflux;
Stage #2: with waterCooling with ice;
Steps:
4.1.3. General procedure for the synthesis of compounds 2a-2d
General procedure: Compounds 1a-d (0.01 mol) in formic acid (20 mL, 85%) was refluxed for 8 h. The reaction mixture was cooled, poured onto ice-water to give a precipitate which was filtered, dried, and recrystallized from ethanol to afford 2a-2d.
References:
Mohamed, Mosaad S.;Hussein, Waleed M.;McGeary, Ross P.;Vella, Peter;Schenk, Gerhard;Abd El-Hameed, Rania H. [European Journal of Medicinal Chemistry,2011,vol. 46,# 12,p. 6075 - 6082] Location in patent:experimental part
![2-[(4-methylphenyl)amino]-1-phenylethanone](/CAS/20180601/GIF/4831-18-9.gif)
4831-18-9
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865546-60-7
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106-49-0
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70-11-1
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865546-60-7
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