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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE
89151-45-1

1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE synthesis

6synthesis methods
89151-44-0 Synthesis
1-Boc-4-(2-hydroxyethyl)piperidine

89151-44-0
235 suppliers
$8.00/1g

98-59-9 Synthesis
Tosyl chloride

98-59-9
615 suppliers
$9.00/5g

1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE

89151-45-1
41 suppliers
$45.00/50mg

-

Yield:89151-45-1 100%

Reaction Conditions:

with dmap in dichloromethane at 20; for 18 h;

Steps:

a

To a solution of 4-(2-Hydroxy-ethyl)-piperidine-l-carboxylic acid tert-butyl ester in DCM (0.65 mmol/mL) p-toluensulphonyl chloride (1.5 eq) and dimethylaminopyridine (1 eq) were added. The reaction was left at rt for 18h and then TLC showed complete conversion of the starting material.The mixture was washed with NaOH 2N and then with HCl 2N, the organic phase was dried over Na2SO4 and then concentrated under reduced pressure. The oil obtained was purified with SiO2 column, eluting with DCM, giving the pure product in quantitative yield.IH-NMR (400MHz, CDC13): 1.01-1.15 (m,2H), 1.44 (s, 9H), 1.47-1.57 (m, 2H), 1.62-1.72 (m, 3H), 2.44 (s, 3H), 2.54-2.65 (m, 2H), 3.95- 4.1 (m, 4H), 7.36 (d, 2H, J=7.3), 7.78 (d, 2H, J=7.3).

References:

WO2007/82731,2007,A1 Location in patent:Page/Page column 14-15

622-26-4 Synthesis
4-Piperidineethanol

622-26-4
206 suppliers
$7.00/250mg

1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE

89151-45-1
41 suppliers
$45.00/50mg

References
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
863 suppliers
$13.50/25G

1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE

89151-45-1
41 suppliers
$45.00/50mg

References
79099-07-3 Synthesis
N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3
0 suppliers
$5.00/5g

1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE

89151-45-1
41 suppliers
$45.00/50mg

References
tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

135716-08-4
143 suppliers
$5.00/250mg

1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE

89151-45-1
41 suppliers
$45.00/50mg

References

1-BOC-4-[2-(TOLUENE-4-SULFONYLOXY)-ETHYL]-PIPERIDINE Related Search:

TERT-BUTYL N-[5-(TOSYLOXY)PENTYL]CARBAMATE