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ChemicalBook CAS DataBase List Amisulpride

Amisulpride synthesis

8synthesis methods
-

Yield:71675-85-9 100%

Reaction Conditions:

in triethylamine;acetone;

Steps:

V Levorotatory N-[1-ethyl 2-pyrrolidylmethyl] 2-methoxy 4-amino 5-ethylsulphonyl benzamide

Levorotatory N-[1-ethyl 2-pyrrolidylmethyl] 2-methoxy 4-amino 5-ethylsulphonyl benzamide Following the same procedure as in Example I, 104 g of 2-methoxy 4-amino 5-ethylsulphonyl benzoic acid dissolved in 380 ml of acetone, in the presence of 38 g of triethylamine, is treated with 41 g of ethyl chloroformate then with 58 g of levorotatory 1-ethyl 2-aminomethyl pyrrolidine. 140 g of levorotatory N[1-ethyl 2-pyrrolidylmethyl] 2-methoxy 4-amino 5-ethylsulphonyl benzamide is obtained (yield 100%).

References:

US4294828,1981,A

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