ChemicalBook CAS DataBase List Amoxicillin

Amoxicillin synthesis

3synthesis methods

Product Name:Amoxicillin
CAS Number:26787-78-0
Molecular formula:C16H19N3O5S
Molecular Weight:365.4

Amoxycillin, [2S-[2α,5α,6β(S)]]-3,3-dimethyl-7-6-[[amino-(4-hydroxyphenyl)-acetyl]amino]-4-thia-1-azabicyclo[3.2.0]-heptan-2-carboxylic acid (32.1.1.21), is synthesized in two ways. The first uses an enamine protection of the amino group of 4-hydroxyphenylglycine, which begins with the sodium salt of 4-hydroxyphenylglycine, which is reacted with the acetoacetic ester to form an enamine—the sodium salt of a phydroxyphenyl acetic acid, α-[(3-ethoxy-1-methyl-3-oxo-1-propenyl)amino]-4-hydroxy- (32.1.1.19). Reacting the resulting aminocrotonate with the ethyl chloroformate in N-methylmorpholine gives the corresponding mixed anhydride (32.1.1.20), which is reacted with trimethylsilyl ester of 6-APA.

The second method uses a direct reaction of D-(-)-2-(4-hydroxyphenyl)glycine chloride hydrochloride with trimethylsylil ester of 6-APA.

The trimethylsilyl ester of 6-APA needed for the reaction is in turn synthesized by reacting trimethylchlorosilylane with 6-APA in the presence of trimethylamine.

73590-58-6 Synthesis

73590-58-6
728 suppliers
$5.00/100mg

26787-78-0
618 suppliers
$5.00/1g

Yield:-

Steps:

1.4 Production of the Pharmaceutical Composition for the Eradication of Helicobacter pylori in the Suspension Form

(4) Omeprazole was added into the above mixture and passed through a sieve (number 60) to form omeprazole/amoxicillin/clarithromycin granules;

References:

US2011/160156,2011,A1

Propanimidamide, 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)-, (Z)- (9CI)

732216-08-9
0 suppliers
inquiry

26787-78-0
618 suppliers
$5.00/1g

References

Guanidine, N''-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]-, (E)- (9CI)

752934-25-1
0 suppliers
inquiry

26787-78-0
618 suppliers
$5.00/1g

References

Amoxicillin Related Search:

Dimethyl phthalate N,N-Dimethyl-1,4-phenylenediamine Dimethyl ether Dimethyl sulfoxide Dimethyl sulfone N,N-Dimethylacetamide

HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links | Privacy | Terms | Product Manufacturers | New Products
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.