ChemicalBook CAS DataBase List Chloromethyl acetate

Chloromethyl acetate synthesis

6synthesis methods

Product Name:Chloromethyl acetate
CAS Number:625-56-9
Molecular formula:C3H5ClO2
Molecular Weight:108.52

75-36-5 Synthesis

75-36-5
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$17.92/100G

625-56-9
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$50.00/1g

Yield:625-56-9 94%

Reaction Conditions:

with formaldehyd;zinc(II) chloride at 0 - 90; for 19 h;Inert atmosphere;

Steps:

49.1 Synthesis of chloromethyl acetate
Acetyl chloride (5g,0.O6mol)was addeddropwisetoamixtureofparaform-aldhyde (8.5 g, 0.06 mol) and anhydrous zinc chloride(0.175 g, 0.02 mol) at 0° C. under Argon. The reaction mixture was warmed to room temperature and stirred for 1hour, then heated to 90° C. for 18 hours. The solid was filtered off washed with dichloromethane, and the filtrate was concentrated under vacuum at 37° C. to provide thedesired product (6.6 g, 94% yield). The product was useddirectly (without purification) in to next step and stored with activated molecular sieves (4° A).

References:

Alkermes Pharma Ireland Limited;Blumberg, Laura Cook;Remenar, Julius F.;Almarsson, Orn;Zeidan, Tarek A. US9102618, 2015, B2 Location in patent:Page/Page column 426

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50-00-0 Synthesis