ChemicalBook CAS DataBase List CYAZOFAMID

CYAZOFAMID synthesis

5synthesis methods

Product Name:CYAZOFAMID
CAS Number:120116-88-3
Molecular formula:C13H13ClN4O2S
Molecular Weight:324.79

4-Chlor-2-cyano-5-(4-methylphenyl)imidazol

120118-14-1
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13360-57-1 Synthesis

13360-57-1
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$30.00/5g

120116-88-3
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$55.00/5 g

Yield:120116-88-3 96.2%

Reaction Conditions:

with potassium carbonate in ethyl acetate for 3 h;Reflux;

Steps:

1.4 Synthesis of 4-chloro-2-cyano-N,N-dimethyl-5-(4'-methylphenyl)-1H-imidazole-1-sulfonamide
With a reflux condenser,Necked flask equipped with a stirrer and a thermometer, 23.6 g (0.1 mol)4 (5) -chloro-2-cyano-5 (4) - (4'-methylphenyl) imidazole, 80 ml of ethyl acetate,16.7 g (0.12 mol) of anhydrous potassium carbonate,16.7 g (0.12 mol) of N, N-dimethylaminosulfonyl chloride,Refluxed for 3 hours,Cooling to room temperature, add 40ml of water, stir, filter,The filter cake was recrystallized from ethyl acetate,Gave a white solid,

References:

Xi'an Modern Chemistry Research Institute;Chen, Tao;Yang, CuiFeng;Su, Tianduo;Ning, binke;Zhang, JianGong;Wang, LiePing;Lin, shuangzheng;Wang, YueMei CN103936678, 2016, B Location in patent:Paragraph 0016; 0017; 0018

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122-00-9 Synthesis