DCU synthesis
- Product Name:DCU
- CAS Number:116-52-9
- Molecular formula:C5H6Cl6N2O3
- Molecular Weight:354.83
13598-36-2
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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121-44-8
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116-52-9
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Yield:-
Reaction Conditions:
in tetrahydrofuran
Steps:
137.I I.
I. (S)-N-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxo-6-[[(phenylmethoxy)carbonyl]amino]hexyl]-N-cyclohexylglycine, phenylmethyl ester A mixture of Part G phosphonic acid (1.040 g, 2.18 mmole, 1.0 eq) and Part H amine·HCl (925 mg, 3.27 mmole, 1.5 eq) in dry THF (20 ml) and Et3 N (0.46 ml, 1.5 eq) was treated with excess N,N-dicyclohexylcarbonyldiimide (DCC) (1.155 g, 2.5 eq) and stirred for 6 hours at room temperature under argon. The suspension was diluted with EtOAc, precipitated DCU filtered off, the filtrate washed with 5% KHSO4, saturated NaHCO3 and brine, then dried over anhydrous Na2 SO4 and evaporated to an oil.
References:
E. R. Squibb & Sons, Inc. US4616005, 1986, A
1000210-73-0
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116-52-9
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116-52-9
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