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Chloral hydrate

Chloral hydrate
Chloral hydrate structure
Chemical Name:
Chloral hydrate
Molecular Formula:
Formula Weight:
MOL File:

Chloral hydrate Properties

Melting point:
57 °C(lit.)
Boiling point:
97 °C
1.43 g/mL at 20 °C
refractive index 
1.4603 (estimate)
Flash point:
16 °C
storage temp. 
Very soluble in water, freely soluble in ethanol (96 per cent).
10(at 25℃)
Specific Gravity
3.5-5.5 (20℃, 10%)
Water Solubility 
660 g/100 mL
Stable, but may be air or light sensitive. Incompatible with alcohols, cyanides, iodine, strong bases, carbonates.
Indirect Additives used in Food Contact Substances
CAS DataBase Reference
302-17-0(CAS DataBase Reference)
175.105; 176.180; 310.545
EWG's Food Scores
NCI Dictionary of Cancer Terms
2A (Vol. 63, 84, 106) 2014
NIST Chemistry Reference
Chloral hydrate(302-17-0)
Proposition 65 List
Chloral Hydrate
EPA Substance Registry System
Chloral hydrate (302-17-0)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H301-H315-H319-H302-H312-H332
Precautionary statements  P301+P310-P305+P351+P338-P280
Hazard Codes  T,F,Xn
Risk Statements  25-36/38-39/23/24/25-23/24/25-11-36/37/38-36-20/21/22
Safety Statements  26-45-25-23-36/37-16-27
RIDADR  UN 3286 3/PG 2
WGK Germany  2
RTECS  FM8750000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29055900
Toxicity LD50 oral in rat: 479mg/kg
NFPA 704
2 1

Chloral hydrate price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 47335-U Chloral hydrate solution 1000μg/mL in acetonitrile, analytical standard 302-17-0 u $31.7 2020-08-18 Buy
Sigma-Aldrich C8383 Chloral hydrate ≥98% (titration) 302-17-0 1kg $294 2020-08-18 Buy
Cayman Chemical 21843 Chloral hydrate ≥95% 302-17-0 5mg $68 2020-06-24 Buy
Cayman Chemical 21843 Chloral hydrate ≥95% 302-17-0 1mg $27 2020-06-24 Buy
Sigma-Aldrich C8383 Chloral hydrate ≥98% (titration) 302-17-0 250g $96.8 2020-08-18 Buy

Chloral hydrate Chemical Properties,Uses,Production

Chemical Properties

colourless crystals with a pentrating odour

Chemical Properties

Chloral is a combustible, oily liquid with a pungent irritating odor.


Trichloroacetaldehyde Hydrate is a useful chemical reagent used as a sedative/hypnotic agent for the short-term treatment of insomnia. First developed in 1832, chloral hydrate is the oldest sleep medication still in use today. This medication is also used to calm you just before surgery or other procedures. It works by affecting certain parts of the brain to cause calmness.
Studies have shown that when used in pediatric sedation side effects such as hallucination, excessive sleep and seizures were observed. Drowsiness and trouble waking up in the morning, nausea, vomiting, stomach pain, diarrhea, and headache may occur. Stomach problems can be reduced by taking chloral hydrate with a full glass of water. It is sometimes administered to patients being treated with cyclophosphamide and it is known to inhibit some aldehyde dehydrogenases.
Besides, Chloral hydrate is a starting point for the synthesis of other organic compounds. It is the starting material for the production of chloral, which is produced by the distillation of a mixture of chloral hydrate and sulfuric acid, which serves as the desiccant.


ChEBI: An organochlorine compound that is the hydrate of trichloroacetaldehyde.

Biological Functions

Chloral hydrate (Noctec, Somnos) was developed in the late 1800s and is still used as a sedative–hypnotic agent. It is a hydrated aldehyde with a disagreeable smell and taste that is rapidly reduced in vivo to trichloroethanol, which is considered to be the active metabolite. It produces a high incidence of gastric irritation and allergic responses, occasionally causes cardiac arrhythmias, and is unreliable in patients with liver damage.

General Description

Chloral hydrate, trichloroacetaldehydemonohydrate, CCl3CH(OH)2 (Noctec), is analdehyde hydrate stable enough to be isolated. The relativestability of this gem-diol is largely a result of an unfavorabledipole–dipole repulsion between the trichloromethyl carbonand the carbonyl carbon present in the parent carbonylcompound.
Chloral hydrate is unstable in alkaline solutions, undergoingthe last step of the haloform reaction to yield chloroformand formate ion. In hydroalcoholic solutions, it formsthe hemiacetal with ethanol. Whether or not this compoundis the basis for the notorious and potentially lethal effect of the combination of ethanol and chloral hydrate (the “MickeyFinn”) is controversial. Synergism between two differentCNS depressants also could be involved. Additionally,ethanol, by increasing the concentration of nicotinamideadenine dinucleotide (NADH), enhances the reduction ofchloral to the more active metabolite trichloroethanol, andchloral can inhibit the metabolism of alcohol because it inhibitsalcohol dehydrogenase. Chloral hydrate is a weak acidbecause its CCl3 group is very strong electron withdrawing.A 10% aqueous solution of chloral hydrate has pH 3.5 to4.4, which makes it irritating to mucous membranes in thestomach. As a result, GI upset commonly occurs for thedrug if undiluted or taken on an empty stomach. Chloral hydrateas a capsule, syrup, or suppository is currently available.

General Description

Transparent colorless crystals or white crystalline solid. Aromatic penetrating slightly acrid odor and a slightly bitter caustic taste. Alcoholic solution (1 in 20) does not at once redden moistened blue litmus paper.

Air & Water Reactions

Water soluble.

Reactivity Profile

Chloral hydrate is incompatible with alkalis, alkaline earth metals, alkali carbonates and soluble barbiturates. Chloral hydrate is decomposed by sodium hydroxide. Chloral hydrate reduces ammoniacal silver nitrate. Chloral hydrate liquefies when triturated with an equal quantity of menthol, camphor or thymol. . Reaction of Chloral hydrate with hydroxylamine produces toxic hydrogen cyanide gas, Org. Synth., 1941, Vol. 1, 377.


Overdose toxic, hypnotic drug, dangerous to eyes. Probable carcinogen.

Fire Hazard

Flash point data for Chloral hydrate are not available; however, Chloral hydrate is probably combustible.

Clinical Use

Although it is suggested that chloral hydrate per semay act as a hypnotic,chloral hydrate is very quickly convertedto trichloroethanol, which is generally assumed toaccount for almost all of the hypnotic effect. Thetrichloroethanol is metabolized by oxidation to chloral andthen to the inactive metabolite, trichloracetic acid, which is also extensively metabolized to acylglucuronidesvia conjugation with glucuronic acid. It appears tohave potent barbiturate-like binding to GABAAreceptors.Although an old drug, it still finds use as a sedative in nonoperatingroom procedures for the pediatric patient.

Safety Profile

A human poison by ingestion and possibly other routes. Poison experimentally by ingestion, intravenous, and rectal routes. Moderately toxic by subcutaneous, parenteral, and intraperitoneal routes, Experimental reproductive effects. Human systemic effects by ingestion: general anesthetic, cardiac arrhythmias, blood pressure depression, eye effects, coma, pulse rate increase, arrhythmias. Human mutation data reported. Questionable carcinogen with experimental carcinogenic and tumorigenic data by skin contact. A sedative, anesthetic, and narcotic. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-.

Potential Exposure

Chloral is used as an intermediate in the manufacture of such pesticides as DDT, methoxychlor, DDVP, naled, trichlorfon, and TCA. Chloral is also used in the production of chloral hydrate; used as a therapeutic agent with hypnotic, sedative, and narcotic effects; used in a time prior to the introduction of barbiturates


Chloral hydrate has not been adequately tested for teratogenicity, reproductive effects, or chronic toxicity. Similarly, no histological evaluations have been conducted.


UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.


Chloral hydrate reacts with strong bases forming chloroform. Contact with acids, or exposure to light may cause polymerization. Reacts with water, forming chloral hydrate. Reacts with oxidizers, with a risk of fire or explosions.

Waste Disposal

Incineration after mixing with another combustible fuel; care must be taken to assure complete combustion to prevent phosgene formation; an acid scrubber is necessary to remove the halo acids produced.

Chloral hydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Chloral hydrate Suppliers

Global( 313)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21842 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22625 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 CHINA 1365 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 24886 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 30039 58
Win-Win Chemical CO., Limited
0086-577-56994596 CHINA 999 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28231 58
Hebei Guanlang Biotechnology Co., Ltd.
whatsapp: +8619930501651 CHINA 2586 58

View Lastest Price from Chloral hydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-08-13 Chloral hydrate
US $65.00 / KG 1KG 99% 20Ton/Tons per Month Hebei Runbin Biotechnology Co. LTD
2020-07-22 Chloral hydrate;Trichloroacetaldehyde hydrate
US $10.00 / Kg/Drum 25KG 99%-102% 100tons/month Hebei Yanxi Chemical Co., Ltd.
2020-06-09 Chloral hydrate Joyce
US $20.00 / KG 1KG 99% 20tons Hebei Guanlang Biotechnology Co., Ltd.

Chloral hydrate Spectrum

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