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Chloral hydrate

Chloral hydrate
Chloral hydrate structure
CAS No.
302-17-0
Chemical Name:
Chloral hydrate
Synonyms
HS;TCA;Escre;Hynos;Tosyl;bi3411;Dormal;Hydral;Noctec;Nortec
CBNumber:
CB0198709
Molecular Formula:
C2H3Cl3O2
Formula Weight:
165.4
MOL File:
302-17-0.mol

Chloral hydrate Properties

Melting point:
57 °C(lit.)
Boiling point:
97 °C
Density 
1.43 g/mL at 20 °C
refractive index 
1.4603 (estimate)
Flash point:
16 °C
storage temp. 
0-6°C
solubility 
Very soluble in water, freely soluble in ethanol (96 per cent).
pka
10(at 25℃)
Specific Gravity
1.91
PH
3.5-5.5 (20℃, 10%)
Water Solubility 
660 g/100 mL
Merck 
13,2080
BRN 
1698497
Stability:
Stable, but may be air or light sensitive. Incompatible with alcohols, cyanides, iodine, strong bases, carbonates.
InChIKey
RNFNDJAIBTYOQL-UHFFFAOYSA-N
CAS DataBase Reference
302-17-0(CAS DataBase Reference)
NIST Chemistry Reference
Chloral hydrate(302-17-0)
EPA Substance Registry System
1,1-Ethanediol, 2,2,2-trichloro-(302-17-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,F,Xn
Risk Statements  25-36/38-39/23/24/25-23/24/25-11-36/37/38-36-20/21/22
Safety Statements  26-45-25-23-36/37-16-27
RIDADR  UN 3286 3/PG 2
WGK Germany  2
RTECS  FM8750000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29055900
Hazardous Substances Data 302-17-0(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Chloral hydrate price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 47335-U Chloral hydrate solution 1000μg/mL in acetonitrile, analytical standard 302-17-0 u $29.9 2018-11-20 Buy
Sigma-Aldrich C8383 Chloral hydrate ≥98% (titration) 302-17-0 1kg $283 2018-11-20 Buy
Cayman Chemical 21843 Chloral hydrate ≥95% 302-17-0 1mg $27 2018-11-19 Buy
Cayman Chemical 21843 Chloral hydrate ≥95% 302-17-0 5mg $68 2018-11-19 Buy
Sigma-Aldrich C8383 Chloral hydrate ≥98% (titration) 302-17-0 250g $93.2 2018-11-20 Buy

Chloral hydrate Chemical Properties,Uses,Production

Chemical Properties

colourless crystals with a pentrating odour

Chemical Properties

Chloral is a combustible, oily liquid with a pungent irritating odor.

Uses

Trichloroacetaldehyde Hydrate is a useful chemical reagent used as a sedative/hypnotic agent for the short-term treatment of insomnia. First developed in 1832, chloral hydrate is the oldest sleep medication still in use today. This medication is also used to calm you just before surgery or other procedures. It works by affecting certain parts of the brain to cause calmness.
Studies have shown that when used in pediatric sedation side effects such as hallucination, excessive sleep and seizures were observed. Drowsiness and trouble waking up in the morning, nausea, vomiting, stomach pain, diarrhea, and headache may occur. Stomach problems can be reduced by taking chloral hydrate with a full glass of water. It is sometimes administered to patients being treated with cyclophosphamide and it is known to inhibit some aldehyde dehydrogenases.
Besides, Chloral hydrate is a starting point for the synthesis of other organic compounds. It is the starting material for the production of chloral, which is produced by the distillation of a mixture of chloral hydrate and sulfuric acid, which serves as the desiccant.

Definition

ChEBI: An organochlorine compound that is the hydrate of trichloroacetaldehyde.

General Description

Transparent colorless crystals or white crystalline solid. Aromatic penetrating slightly acrid odor and a slightly bitter caustic taste. Alcoholic solution (1 in 20) does not at once redden moistened blue litmus paper.

General Description

Chloral hydrate, trichloroacetaldehydemonohydrate, CCl3CH(OH)2 (Noctec), is analdehyde hydrate stable enough to be isolated. The relativestability of this gem-diol is largely a result of an unfavorabledipole–dipole repulsion between the trichloromethyl carbonand the carbonyl carbon present in the parent carbonylcompound.
Chloral hydrate is unstable in alkaline solutions, undergoingthe last step of the haloform reaction to yield chloroformand formate ion. In hydroalcoholic solutions, it formsthe hemiacetal with ethanol. Whether or not this compoundis the basis for the notorious and potentially lethal effect of the combination of ethanol and chloral hydrate (the “MickeyFinn”) is controversial. Synergism between two differentCNS depressants also could be involved. Additionally,ethanol, by increasing the concentration of nicotinamideadenine dinucleotide (NADH), enhances the reduction ofchloral to the more active metabolite trichloroethanol, andchloral can inhibit the metabolism of alcohol because it inhibitsalcohol dehydrogenase. Chloral hydrate is a weak acidbecause its CCl3 group is very strong electron withdrawing.A 10% aqueous solution of chloral hydrate has pH 3.5 to4.4, which makes it irritating to mucous membranes in thestomach. As a result, GI upset commonly occurs for thedrug if undiluted or taken on an empty stomach. Chloral hydrateas a capsule, syrup, or suppository is currently available.

Air & Water Reactions

Water soluble.

Reactivity Profile

Chloral hydrate is incompatible with alkalis, alkaline earth metals, alkali carbonates and soluble barbiturates. Chloral hydrate is decomposed by sodium hydroxide. Chloral hydrate reduces ammoniacal silver nitrate. Chloral hydrate liquefies when triturated with an equal quantity of menthol, camphor or thymol. . Reaction of Chloral hydrate with hydroxylamine produces toxic hydrogen cyanide gas, Org. Synth., 1941, Vol. 1, 377.

Hazard

Overdose toxic, hypnotic drug, dangerous to eyes. Probable carcinogen.

Fire Hazard

Flash point data for Chloral hydrate are not available; however, Chloral hydrate is probably combustible.

Clinical Use

Although it is suggested that chloral hydrate per semay act as a hypnotic,chloral hydrate is very quickly convertedto trichloroethanol, which is generally assumed toaccount for almost all of the hypnotic effect. Thetrichloroethanol is metabolized by oxidation to chloral andthen to the inactive metabolite, trichloracetic acid, which is also extensively metabolized to acylglucuronidesvia conjugation with glucuronic acid. It appears tohave potent barbiturate-like binding to GABAAreceptors.Although an old drug, it still finds use as a sedative in nonoperatingroom procedures for the pediatric patient.

Safety Profile

A human poison by ingestion and possibly other routes. Poison experimentally by ingestion, intravenous, and rectal routes. Moderately toxic by subcutaneous, parenteral, and intraperitoneal routes, Experimental reproductive effects. Human systemic effects by ingestion: general anesthetic, cardiac arrhythmias, blood pressure depression, eye effects, coma, pulse rate increase, arrhythmias. Human mutation data reported. Questionable carcinogen with experimental carcinogenic and tumorigenic data by skin contact. A sedative, anesthetic, and narcotic. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Cl-.

Potential Exposure

Chloral is used as an intermediate in the manufacture of such pesticides as DDT, methoxychlor, DDVP, naled, trichlorfon, and TCA. Chloral is also used in the production of chloral hydrate; used as a therapeutic agent with hypnotic, sedative, and narcotic effects; used in a time prior to the introduction of barbiturates

First aid

Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Chloral hydrate reacts with strong bases forming chloroform. Contact with acids, or exposure to light may cause polymerization. Reacts with water, forming chloral hydrate. Reacts with oxidizers, with a risk of fire or explosions.

Waste Disposal

Incineration after mixing with another combustible fuel; care must be taken to assure complete combustion to prevent phosgene formation; an acid scrubber is necessary to remove the halo acids produced.

Chloral hydrate Preparation Products And Raw materials

Raw materials

Preparation Products


Chloral hydrate Suppliers

Global( 256)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
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0371-55170693
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View Lastest Price from Chloral hydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-10 Chloral hydrate
302-17-0
US $1.00 / g 10g 99% min 1000 Kilogram/Kilograms per Month Cangzhou Wanyou New Material Technology Co.,Ltd
2018-12-17 Chloral hydrate
302-17-0
US $7.00 / kg 1kg 99% 100kg career henan chemical co

Chloral hydrate Spectrum


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