ChemicalBook CAS DataBase List Chloral hydrate

Chloral hydrate synthesis

12synthesis methods

Product Name:Chloral hydrate
CAS Number:302-17-0
Molecular formula:C2H3Cl3O2
Molecular Weight:165.4

Chloral hydrate, 2,2,2-trichloro-1,1-ethandiol (4.3.1), is synthesized either by chlorination of ethanol or chlorination of acetaldehyde and the subsequent addition of water molecules to the resulting trichloroacetic aldehyde [31].

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Yield:302-17-0 45%

Reaction Conditions:

in tetrachloromethane;

Steps:

5 EXAMPLE 5

EXAMPLE 5 20 g of the propylene glycol ester of alginic acid was suspended in 50 ml. carbon tetrachloride and 20 ml. anhydrous chloral added. The mixture was stirred on a steam bath for 30 minutes, cooled, filtered, washed with carbon tetrachloride and at 45° C. A product containing 45% calculated as chloral hydrate was obtained. This is an example of reaction with compounds of type VI as previously described.

References:

US4272526,1981,A