
Dibenzofuran-4-boronic acid synthesis
- Product Name:Dibenzofuran-4-boronic acid
- CAS Number:100124-06-9
- Molecular formula:C12H9BO3
- Molecular Weight:212.01

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5419-55-6
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100124-06-9
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Yield:100124-06-9 94%
Reaction Conditions:
Stage #1: 4-bromodibenzofuranwith n-butyllithium in tetrahydrofuran at -78; for 1.5 h;Inert atmosphere;
Stage #2: Triisopropyl borate in tetrahydrofuran at 20; for 8 h;
Steps:
4.1 (5-(4-([2,2':6',2"-teridopyridine]-4'-yl)phenyl)-5H-benzofuro[3,2-c]indole)Preparation
(1) 4-bromodibenzofuran (7.4 g, 30 mmol, 1 eq) in a 50 ml three-necked flask,Add dry tetrahydrofuran solution, cool to -78 ° C, replace N2, three times,To ensure the oxygen-free environment of the system, add n-butyl lithium (2.5M, 13.2ml,After 33 mmol, 1.1 eq), the reaction was kept at -78 ° C for 1.5 h, and triisopropyl borate (ρ = 0.815 g/ml, 7.6 ml, 33 mmol, 1.1 eq) was added dropwise. After the addition was completed, the temperature was raised to room temperature for 8 h. After the dropwise addition of dilute hydrochloric acid, the reaction was quenched, distilled under reduced pressure to give tetrahydrofuran, dissolved in dichloromethane, washed with anhydrous magnesium sulfate, dried, filtered, and the filtrate was recrystallized.White solid product4-boronic acid dibenzofuran6 g (yield 94%).
References:
CN109897029,2019,A Location in patent:Paragraph 0063-0066

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100124-06-9
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132-64-9
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100124-06-9
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