ChemicalBook CAS DataBase List DICLOFENAC METHYL ESTER

DICLOFENAC METHYL ESTER synthesis

9synthesis methods

Product Name:DICLOFENAC METHYL ESTER
CAS Number:15307-78-5
Molecular formula:C15H13Cl2NO2
Molecular Weight:310.18

67-56-1 Synthesis

67-56-1
726 suppliers
$7.29/5ml-f

15307-86-5
364 suppliers
$48.00/25g

15307-78-5
81 suppliers
$35.00/10mg

Yield: 96%

Reaction Conditions:

with sulfuric acid for 0.25 h;Reflux;

Steps:

3.1.4.2. Diclofenac Methyl Ester (2)
Diclofenac acid (5 g) was dissolved in methanol (80 mL)with stirring and sulfuric acid (3 mL) was added drop wisewith continuous stirring and the mixture was heated underreflux for 15 min. After completion of the reaction (TLCanalysis), it was cooled to room temperature and poured ontocrushed ice (250 g) to obtain crystalline solid (2) which wasfiltered, washed with water followed by 5% sodium hydrogencarbonate solution, finally with water and dried in air.

References:

Shah, Shazia;Arshia;Kazmi, Nida Siraj;Jabeen, Almas;Khan, Khalid Mohammed;Raza, Abeer;Faheem, Aisha;Dastagir, Nida;Ahmed, Tariq;Ahmed, Shakil;Perveen, Shahnaz [Medicinal Chemistry,2018,vol. 14,# 7,p. 674 - 687]

57486-69-8 Synthesis