DIETHYL-(4-METHOXY-PHENYL)-AMINE synthesis
- Product Name:DIETHYL-(4-METHOXY-PHENYL)-AMINE
- CAS Number:15144-80-6
- Molecular formula:C11H17NO
- Molecular Weight:179.26
Yield:15144-80-6 100%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide at 0 - 20; for 15 h;
Steps:
7 Preparation of Compounds (14)
A solution of 4-methoxyaniline (Compound (13)) (10.0 g, 81.2 mmol) in DMF (100 mL) was treated with 60% NaH (8.10 g, 203 mmol) and iodoethane (26.0 mL, 235 mmol). The temperature of the mixture was kept at 0°C by ice bath in the first 3 hours of stirring. The ice bath was removed and the mixture was stirred at room temperature for another 12 hours. Water (200 mL) was added to quench this reaction. The product was extracted by ethyl acetate (200 mL x 3). The combined organic layers were washed by water (200 mL x 5), brine (200 mL), and dried over sodium sulfate. Filtration and evaporation gave Compound (14) (16.2 g, -100%) as a dark green oil
References:
WO2013/180811,2013,A1 Location in patent:Paragraph 0310
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