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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List Ketoconazole

Ketoconazole synthesis

7synthesis methods
Ketoconazole, cis-1-acetyl-4-[4-[2-(2,4-dichlorophenyl)-2-(1H-imidazole- 1-ylmethyl)-1,3-dioxolan-4-ylmethyl]phenyl]piperazine (35.2.4), is synthesized from 2,4-dichlorophenacyl bromide, the ketalization of which using glycerol gives cis-2-(2,4- dichlorophenyl)-2-bromoethyl-4-hydroxymethyl-1,3-dioxolane (35.2.1). Acylating the hydroxyl group of this compound with benzoyl chloride, and then alkylating the resulting compound with imidazole gives the derivative (35.2.2). Next, alkaline hydrolysis removes the benzoyl group, and a reaction with methanesulfonyl chloride gives a mesylate (35.2.3). Finally, alkylating the resulting 1-acetyl-4-(4-hydroxyphenyl)piperazine gives ketoconazole (35.2.4).

170210-42-1 Synthesis
Ketoconazole Impurity 9 (Ketoconazole Hydroxymethyl Impurity)

170210-42-1
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Ketoconazole

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-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: pyridine
2: NaH / dimethylsulfoxide / 0 - 80 °C

References:

Power, Eoin C.;Ganellin, C. Robin;Benton, David C.H. [Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,# 4,p. 887 - 890]

56621-48-8 Synthesis
1-(4-Hydroxyphenyl)piperazine

56621-48-8
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Ketoconazole

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References
133345-21-8 Synthesis
Loratadine Side Chain Impurity

133345-21-8
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Ketoconazole

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References
541-73-1 Synthesis
1,3-Dichlorobenzene

541-73-1
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Ketoconazole

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References
Piperazine, 1-acetyl-4-(4-hydroxyphenyl)-, cis- (9CI)

89929-31-7
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Ketoconazole

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References

Ketoconazole Related Search:

1,4-Dioxane Acetylacetone Dichlorodiphenylsilane Acetyl chloride tert-Butyl carbamate cis-2,6-Dimethylpiperazine 4-(1-Acetylpiperazin-4-yl)phenol cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine Ketoconazole Impurity 9 (Ketoconazole Hydroxymethyl Impurity) Ketoconazole Impurity 3