ChemicalBook CAS DataBase List Ethanone, 1-[4-(methylamino)phenyl]- (9CI)

Ethanone, 1-[4-(methylamino)phenyl]- (9CI) synthesis

12synthesis methods

Product Name:Ethanone, 1-[4-(methylamino)phenyl]- (9CI)
CAS Number:17687-47-7
Molecular formula:C9H11NO
Molecular Weight:149.19

99-90-1
460 suppliers
$6.00/25g

74-89-5 Synthesis

74-89-5
7 suppliers
$13.44/25ML

Ethanone, 1-[4-(methylamino)phenyl]- (9CI)

17687-47-7
75 suppliers
$16.00/100mg

Yield: 94%

Reaction Conditions:

with copper in water at 100; for 18 h;

Steps:

To the pressure-resistant tube was added 4-bromoacetophenone 5 g (25.12 mmol), copper powder 0.08 g (1.26 mmol) aqueous methylamine solution (13 mL, 30%). The pressure tube seal was heated to 100 ° C in an oil bath for 18 h, and the reaction solution was cooled to room temperature, then extracted with ethyl acetate (3×100 mL), the organic phase was combined, washed with brine, dried over anhydrous sodium sulfate Development solvent petroleum ether: ethyl acetate = 5:1, 200-300 mesh silica gel column chromatography to give compound 33.53 g, yield 94%

References:

Tianjin University of Science and Technology;Teng Yuou;Xiang Cen;Cao Menglin;Gao Feng;Cui Shanshan;Rong Yao;Zhao Lianbo;Hao Lei;Wang Dong;Yu Peng CN110143890, 2019, A Location in patent:Paragraph 0047

67-56-1 Synthesis