Ethoxyquin synthesis
- Product Name:Ethoxyquin
- CAS Number:91-53-2
- Molecular formula:C14H19NO
- Molecular Weight:217.31
156-43-4
67-64-1
91-53-2
The general procedure for the synthesis of ethoxyquinoline from p-ethoxyaniline and acetone was as follows: 100 kg of p-aminoanisole, 30 kg of the solvent acetic anhydride and 5 kg of the catalyst cuprous chloride were added to the reaction tank and mixed thoroughly. Subsequently, the reaction mixture was heated to 130°C, and the titration rate of acetone was controlled by a rotameter at atmospheric pressure, and a total of 210 kg of acetone was titrated. The reaction lasted for 12 hours, during which the content of ethoxyquinoline in the reaction mixture was determined periodically. When the content of ethoxyquinoline reached 90% or higher, the reaction mixture was cooled to 75°C. Water and unreacted acetone produced during the reaction were recovered by condensation and the acetone was recycled.
Yield:91-53-2 92%
Reaction Conditions:
at 60 - 110; under 760.051 Torr; for 8 h;Ionic liquid;Temperature;
Steps:
1; 2; 3; 4 Example 4
68.5 g of p-aminophenyl ether,20g of ionic liquid,It is metered into the reactor at one time, fully mixed, heated and heated,At a reaction temperature of 110 ° C,70 g of acetone was added dropwise under normal pressure,The reaction time is 8h,Reduce the temperature of the reaction solution to below 60 ° C.Unreacted acetone is condensed and recovered into the acetone recoverer;The reaction solution was washed with water to separate the lower catalyst aqueous solution, and the catalyst was recycled.The upper ethoxyquinoline feed liquid separated by washing with water was distilled to obtain a finished product, and the yield was 92%.
References:
Nanjing Tech University;Zhuang Linghua;Tang Yang;Wu Jinyong CN110272385, 2019, A Location in patent:Paragraph 0019-0026
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$5.00/5 g
91-53-2
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$15.00/10g
123-42-2
599 suppliers
$19.00/100ml
156-43-4
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$5.00/5 g
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91-53-2
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$15.00/10g