Ethyl 2-(3-Chlorophenyl)sulfanylacetate synthesis
- Product Name:Ethyl 2-(3-Chlorophenyl)sulfanylacetate
- CAS Number:141819-39-8
- Molecular formula:C10H11ClO2S
- Molecular Weight:230.7111
Yield:141819-39-8 94%
Reaction Conditions:
with potassium carbonate in acetonitrile at 50; for 24 h;
Steps:
35.a
EXAMPLE 35; 2-(3-Chlorophenylthio)-N'-((8-methylquinolin-6- yl)methylene)acetohydrazide; [0562] (a) Ethyl 2-(3-chlorophenylthio)acetate: To a stirred solution of 3- chlorobenzenethiol (0.5 g, 3.45 mmol) in CH3CN (7 mL) was added ethyl 2- bromoacetate (0.4 mL, 3.45 mmol) and K2CO3 (0.95 g, 6.91 mmol). The reaction mixture was heated to 50 0C and stirred for 24 hours by which time the reaction mixture had become a white slurry. The reaction was diluted with EtOAc and washed with water and brine. The organic layer was dried (Na2SO4), filtered and concentrated. The product (0.75 g, 94%) was used without further purification.
References:
WO2010/132615,2010,A1 Location in patent:Page/Page column 126
![Benzene, 1-chloro-3-[(1-methylethyl)thio]-](/CAS/20180629/GIF/55698-06-1.gif)
2037-31-2
154 suppliers
$19.00/1g
141819-39-8
5 suppliers
inquiry
