Ethyl 2-chloroethoxyl acetic acid synthesis
- Product Name:Ethyl 2-chloroethoxyl acetic acid
- CAS Number:17229-14-0
- Molecular formula:C6H11ClO3
- Molecular Weight:166.6
105-36-2
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107-07-3
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$21.53/50ml
17229-14-0
151 suppliers
$25.00/10g
Yield:17229-14-0 60% w/w
Reaction Conditions:
in N-methyl-acetamide;toluene;mineral oil;
Steps:
1 Ethyl 2-chloroethoxyacetate
PREPARATION 1 Ethyl 2-chloroethoxyacetate A suspension of 25.0 g of sodium hydride (as a 60% w/w suspension in mineral oil) in 100 ml of dimethylformamide was added dropwise to a solution of 50 g of 2-chloroethanol and 104 g of ethyl bromoacetate in 350 ml of dimethylformamide at between -45° C. and -40 C., and the mixture was stirred at the same temperature for 1 hour, at between -30° C. and -25° C. for 2 hours, at -5° C.-5° C. for 1 hour and then at room temperature for 2 hours. At the end of this time, it was concentrated by evaporation under reduced pressure, and 1000 ml of toluene were added to the residue. The solution was then washed with water, and the solvent was removed by evaporation under reduced pressure. Distillation gave 77.6 g (yield 75%) of the title compound, boiling at 57°-58° C./2.5 mmHg (333 Pa). Nuclear Magnetic Resonance Spectrum (CDCl3), δ ppm: 1.30 (3H, triplet, J=7.0 Hz); 3.70 (2H, triplet, J=4.5 Hz); 3.84 (2H, triplet, J=4.5 Hz); 4.15 (2H, singlet); 4.22 (2H, quartet, J=7.0 Hz);
References:
US5362725,1994,A
64-17-5
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3041-16-5
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17229-14-0
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$25.00/10g
75-21-8
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$39.10/1mL
105-39-5
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17229-14-0
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$25.00/10g
64-17-5
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31250-08-5
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17229-14-0
151 suppliers
$25.00/10g