ETHYL 3,4,5-TRIMETHOXYPHENYL ACETATE synthesis

5synthesis methods

Product Name:ETHYL 3,4,5-TRIMETHOXYPHENYL ACETATE
CAS Number:66162-60-5
Molecular formula:C13H18O5
Molecular Weight:254.28

64-17-5 Synthesis

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Yield:66162-60-5 99%

Reaction Conditions:

with sulfuric acid in toluene;Reflux;

Steps:

1 Example 1: Ethyl 2- (3,4,5-trimethoxyphenyl) acetate (1).

2- (3,4,5-trimethoxyphenyl)Acetic acid (90.5 g, 0.4 mol),Anhydrous ethanol (120 mL) and concentratedH2SO4 (8 mL) was added to toluene (500 mL)Reflux overnightWater Separator.After completion of the reaction,EtOAc (400 mL), Washed sequentially with 1 N aqueous NaOH (50 mL) and brine,Na2SO4 dried,Concentration under reduced pressure gave compound 1 as pale yellowOil (100.6 g, 99% yield).1H NMR (300 MHz, CDCl3)? 6.52 (s, 2H), 4.18 (q, J = 7.1 Hz, 2H)3.87 (s, 6H), 3.85 (s, 3H), 3.56 (s, 2H), 1.29 (t, J = 7.1 Hz, 3H) .ESI-MS m / z = 255.24 [M + 1

References:

CN104649879,2017,B Location in patent:Paragraph 0069; 0070

951-82-6
281 suppliers
$19.00/5g

66162-60-5
12 suppliers
inquiry

References

86-81-7 Synthesis