Ethyl 6,8-dichlorooctanoate synthesis
- Product Name:Ethyl 6,8-dichlorooctanoate
- CAS Number:1070-64-0
- Molecular formula:C10H18Cl2O2
- Molecular Weight:241.15
1070-65-1
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1070-64-0
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Yield:1070-64-0 96.69%
Reaction Conditions:
with phosgene;N,N'-dimethylbenzylamine in 1,2-dichloro-ethane at 10 - 75; for 2.5 h;Concentration;Solvent;Reagent/catalyst;Temperature;
Steps:
8 Example 8
Dichloroethane in the organic solvent, 6-hydroxy -Chloro - octanoic acid ethyl ester with chlorinated reagent solid phosgene inN, N-dimethyl benzyl amine for the acid-binding agentEthyl 6-hydroxy-8-chlorooctanoate,Chlorination reagents,N, N-dimethylbenzylamine molar ratio1: 1.05: 0.12,The organic solvent was reacted with 6-hydroxy-8-The weight ratio of ethyl chlorocaprylate was1: 2.4 at a temperature ofN, N-dimethylbenzylamine was added dropwise at 10 ° C,Insulation temperature of 75 ,Insulation time 150min,In the reaction solution obtained,Water layer, water and 6 - hydroxy -8-chloro-ethyl octanoate weight ratio of 1:3, the upper organic phase.Vacuum distillation to collect vacuum 5mmHg,A temperature of 172-176 ° C,Ethyl 6,8-dichlorooctanoate,Product mol yield 95.68%, Purity 96.65%The bottom of the liquid base to adjust the pH value of 11,Layered,The upper layer was dewatered with sodium sulfateN, N-dimethylbenzylamine,The molar yield of the product was 96.69%Purity 99.71%.
References:
CN105693510,2016,A Location in patent:Paragraph 0047; 0048; 0049
626-86-8
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1070-64-0
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22054-13-3
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1070-64-0
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6149-48-0
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1070-64-0
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