Ethyl 8-bromooctanoate synthesis
- Product Name:Ethyl 8-bromooctanoate
- CAS Number:56703-12-9
- Molecular formula:C10H19IO2
- Molecular Weight:298.16
29823-21-0
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Yield:56703-12-9 93.2%
Reaction Conditions:
with sodium iodide in acetone at 60; for 18 h;Inert atmosphere;
Steps:
D.i Ethyl 8-iodooctanoate
A mixture of ethyl 8-bromooctanoate (5g, 19.9mmol) and sodium iodide (2.98g, 19.9mmol) in Acetone (5OmL) was heated at 60°C under nitrogen for 18h. The reaction mixture was then concentrated under vacuum. Purification by silica gel column chromatography, using EtOAc/Hexane (1:90) as eluant, provided ethyl 8- iodooctanoate as a colourless liquid (5.5g, 93.2 %).LCMS (ES): Found 299.2 [MH]+.
References:
WO2014/72714,2014,A1 Location in patent:Page/Page column 24; 25
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