
ETHYL THIOPHENE-2-GLYOXYLATE synthesis
- Product Name:ETHYL THIOPHENE-2-GLYOXYLATE
- CAS Number:4075-58-5
- Molecular formula:C8H8O3S
- Molecular Weight:184.21

33898-90-7
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$8.00/1g

64-17-5
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$10.00/50g

4075-58-5
111 suppliers
$19.00/1g
Yield: 82%
Reaction Conditions:
with [bis(acetoxy)iodo]benzene in dichloromethane for 2 h;Reflux;
Steps:
Ethyl 2-thienylglyoxylate 3m
General procedure: β-Oxo-benzenepropanenitrile 1(1.0 mmol),PIDA (2.2 mmol) were dissolved in EtOH (8 mL) and stirred under refluxing for 0.5h. After the reaction was completed (monitored by TLC), thereaction mixture was concentrated under vacuum. The residue was purified by chromatographyon silica gel (20:1 petroleum ether/EtOAc) to give the product 3a-o .Thesolvent for the synthesis of 3o was MeOH.
References:
Xie, Yuanyuan;Liu, Jiwei;Huang, Yingyi;Yao, Lixia [Tetrahedron Letters,2015,vol. 56,# 24,p. 3793 - 3795] Location in patent:supporting information

5713-61-1
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95-92-1
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$5.00/5 g

4075-58-5
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$19.00/1g

1003-09-4
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$10.00/25g

95-92-1
432 suppliers
$5.00/5 g

4075-58-5
111 suppliers
$19.00/1g