ChemicalBook CAS DataBase List Isopropyl Itraconazole

Isopropyl Itraconazole synthesis

8synthesis methods

Product Name:Isopropyl Itraconazole
CAS Number:89848-49-7
Molecular formula:C34H36Cl2N8O4
Molecular Weight:691.61

38212-30-5
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89848-49-7
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Yield:-

Steps:

Multi-step reaction with 8 steps
1: 67 percent / K₂CO₃ / dimethylsulfoxide / 120 °C
2: 74 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating
3: 61 percent / pyridine / CHCl₃ / 3 h
4: 63 percent / hydrazine hydrate / dioxane / 3 h / Heating
5: 28 percent / NaOAc / butan-1-ol
6: 47 percent / KOH / dimethylsulfoxide / 14 h
7: 86 percent / 48percent aq. HBr / Heating
8: 1.) NaH / 1.) Me₂SO, 50 deg C, 1 h, 2.) Me₂SO, 100 deg C, 3 h

References:

Heeres;Backx;Van Cutsem [Journal of Medicinal Chemistry,1984,vol. 27,# 7,p. 894 - 900]

1-(4-Methoxyphenyl)-4-(4-nitrophenyl)piperazine

74852-61-2
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89848-49-7
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References

1-(4-AMINOPHENYL)-4-(4-METHOXYPHENYL)PIPERAZINE

74852-62-3
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$26.57/5G

89848-49-7
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References

74853-07-9 Synthesis

2,4-dihydro-4-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one

74853-07-9
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89848-49-7
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References

74852-89-4 Synthesis

Hydrazine Carboxamide,N-{4-[4(4-methoxyphenyl)-1-pipezinyl]phenyl}

74852-89-4
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89848-49-7
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References

Isopropyl Itraconazole Related Search:

DPUDRFOQNBKHMF-YZNIXAGQSA-N 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol Itraconazole 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- Itraconazole Impurity 24 Cis -Tosylate

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