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ChemicalBook CAS DataBase List Itraconazole

Itraconazole synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: hydrogen bromide / lithium hydroxide monohydrate; toluene / 12 h / Reflux
2: potassium carbonate / (methylsulfinyl)methane / 5 h / 90 °C

References:

Cai, Jin;Chen, Xixi;You, Haoyuan;Li, Xiaojing;Ji, Min [Bioorganic and Medicinal Chemistry Letters,2022,vol. 76,art. no. 129011]

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