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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List MCPB
94-81-5

MCPB synthesis

6synthesis methods
The industrial production of MCPB begins with the chlorination of o-cresol (2-methylphenol) to introduce a chlorine atom at the 4-position, forming 4-chloro-2-methylphenol. This intermediate is then reacted with 1,4-dibromobutane or similar butanoic acid precursors in an etherification step to form the phenoxybutanoic acid structure. The reaction typically involves base catalysis and controlled heating to ensure selective substitution and minimize side reactions. The resulting crude MCPB is purified through solvent extraction and crystallisation to achieve the desired chemical purity.
4-Chloro-2-methylphenol

1570-64-5
268 suppliers
$5.00/1g

MCPB

94-81-5
87 suppliers
$24.73/250mgs:

-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: potassium carbonate; sodium iodide / 48 h / Reflux; Inert atmosphere
2: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; nickel(II) bromide dimethoxyethane; 2.9-dimethyl-1,10-phenanthroline; C60H36N2 / N,N-dimethyl-formamide / 24 h / 20 °C / Molecular sieve; Irradiation

References:

Meng, Qing-Yuan;Wang, Shun;König, Burkhard [Angewandte Chemie - International Edition,2017,vol. 56,# 43,p. 13426 - 13430][Angew. Chem.,2017,vol. 129,p. 13611 - 13615,5]

Carbon dioxide

124-38-9
721 suppliers
$175.00/23402

Benzene, 1-(3-bromopropoxy)-4-chloro-2-methyl-

50912-62-4
2 suppliers
inquiry

MCPB

94-81-5
87 suppliers
$24.73/250mgs:

References
Carbon dioxide

124-38-9
721 suppliers
$175.00/23402

Benzene, 1-(3-bromopropoxy)-4-chloro-2-methyl-

50912-62-4
2 suppliers
inquiry

584-08-7 Synthesis
Potassium carbonate

584-08-7
1216 suppliers
$5.00/100g

MCPB

94-81-5
87 suppliers
$24.73/250mgs:

References
o-Cresol

95-48-7
430 suppliers
$17.00/25g

MCPB

94-81-5
87 suppliers
$24.73/250mgs:

References
Gamma Butyrolactone

96-48-0
0 suppliers
$21.10/25g

52106-86-2 Synthesis
Sodium 4-chloro-2-methylphenolate

52106-86-2
3 suppliers
inquiry

MCPB

94-81-5
87 suppliers
$24.73/250mgs:

References

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