METHYL 2-METHOXY-5-METHYLBENZOATE 97 synthesis
- Product Name:METHYL 2-METHOXY-5-METHYLBENZOATE 97
- CAS Number:63113-79-1
- Molecular formula:C10H12O3
- Molecular Weight:180.2
89-56-5
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$11.00/5g
74-88-4
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$15.00/10g
63113-79-1
61 suppliers
$12.00/250mg
Yield:63113-79-1 95%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 0 - 20; for 12 h;
Steps:
47 Methyl 2-methoxy-5-methylbenzoate
Reference example 47 Methyl 2-methoxy-5-methylbenzoate To 5-methylsalicylic acid (3.04 g, 20 mmol) in DMF (100 ml) were added potassium carbonate (8.28 g, 60 mmol) and iodomethane (6.24 g, 44 mmol) under ice cooling and then the mixture was stirred at room temperature for 12 hours. The mixture were extracted by adding 5% sodium hydrogensulfite and ethyl acetate, and the extracted organic layer was washed with 5% citric acid and 5% brine. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography (hexane-ethyl acetate) to give the captioned compound (3.43 g, 19.1 mmol, yield: 95%) as a colorless oil.
References:
EP1550662,2005,A1 Location in patent:Page/Page column 28
67-56-1
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25045-36-7
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$9.00/250mg
63113-79-1
61 suppliers
$12.00/250mg
89-56-5
217 suppliers
$11.00/5g
77-78-1
321 suppliers
$22.00/25g
63113-79-1
61 suppliers
$12.00/250mg
22717-57-3
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$14.00/1g
74-88-4
353 suppliers
$15.00/10g
63113-79-1
61 suppliers
$12.00/250mg
606-45-1
261 suppliers
$9.00/10g
63113-79-1
61 suppliers
$12.00/250mg