METHYL 3-(4-(BENZYLOXY)PHENYL)PROPANOATE synthesis
- Product Name:METHYL 3-(4-(BENZYLOXY)PHENYL)PROPANOATE
- CAS Number:24807-40-7
- Molecular formula:C17H18O3
- Molecular Weight:270.32
5597-50-2
100-39-0
24807-40-7
Procedure for the synthesis of methyl 3-(4-(benzyloxy)phenyl)propionate: in 40 mL of acetonitrile, methyl 3-(4-hydroxyphenyl)propionate (1.54 g, 8.55 mmol), potassium carbonate (3.55 g, 25.64 mmol) and benzyl bromide (4.39 g, 25.64 mmol) were mixed to form a suspension. The reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, the mixture was poured into 120 mL of water and the pH was adjusted to 2 with 10% aqueous hydrochloric acid, followed by extraction with ethyl acetate (2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography with 0→5% ethyl acetate/hexane as eluent to give methyl 3-(4-(benzyloxy)phenyl)propionate (2.01 g, white solid, 88% yield).1H NMR (CDCl3, 250 MHz) δ ppm: 7.51-7.29 (m, 5H), 7.14 (d, J = 8.8 Hz, 2H). 6.92 (d, J = 8.8 Hz, 2H), 5.05 (s, 2H), 3.69 (s, 3H), 2.92 (t, J = 7.6 Hz, 2H), 2.62 (t, J = 7.6 Hz, 2H).
![(2E)-3-[4-(PhenylMethoxy)phenyl]-2-propenoic Acid Methyl Ester](/CAS/GIF/84184-51-0.gif)
84184-51-0
15 suppliers
$165.00/100mg
24807-40-7
39 suppliers
$45.00/100mg
Yield:24807-40-7 95%
Reaction Conditions:
with [2,2]bipyridinyl;hydrogen;palladium on activated charcoal in methanol at 20; for 5 h;
References:
Sajiki, Hironao;Kuno, Hiroko;Hirota, Kosaku [Tetrahedron Letters,1998,vol. 39,# 39,p. 7127 - 7130]
5597-50-2
255 suppliers
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100-39-0
438 suppliers
$10.00/10g
24807-40-7
39 suppliers
$45.00/100mg
5597-50-2
255 suppliers
$5.00/1g
100-51-6
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24807-40-7
39 suppliers
$45.00/100mg
67-56-1
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$9.00/25ml
![3-[4-(BENZYLOXY)PHENYL]PROPIONIC ACID](/CAS/GIF/50463-48-4.gif)
50463-48-4
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$44.00/1g
24807-40-7
39 suppliers
$45.00/100mg
5597-50-2
255 suppliers
$5.00/1g
100-44-7
659 suppliers
$13.50/250G
24807-40-7
39 suppliers
$45.00/100mg