Methyl 3-bromo-4-hydroxybenzoate synthesis
- Product Name:Methyl 3-bromo-4-hydroxybenzoate
- CAS Number:29415-97-2
- Molecular formula:C8H7BrO3
- Molecular Weight:231.04
67-56-1
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$7.29/5ml-f
14348-41-5
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$8.00/1g
29415-97-2
173 suppliers
$5.00/1g
Yield:29415-97-2 100%
Reaction Conditions:
with sulfuric acid at 80;Cold solution;
Steps:
Intermediate T3T3.1[0304] Methyl 3-bromo-4-hydroxybenzoate (T3.1). To a stirred solution of 3- bromo-4-hydroxybenzoic acid (available from Alfa Aesar, Avocado, Lancaster) (50.0 g, 231 mmol) in MeOH (300 mL) was added a cold solution of sulfuric acid (2.50 mL, 47 mmol). The mixture was heated to 80°C and monitored by TLC. After 16.5 hours, the solvent was removed and the reaction mixture was diluted with EtOAc. The organic phase was washed carefully two times with saturated aqueous NaHCO3, once with brine, and then dried over anhydrous sodium sulfate. After filtration, the organic solvent was removed in vacuo to yield T3.1 as a white solid (yield 100%) that was used without purification.
References:
AMGEN INC.;BROWN, Sean P.;DRANSFIELD, Paul;DU, Xiaohui;FU, Zice;HOUZE, Jonathan;JIAO, XianYun;LAI, SuJen;LI, An-Rong;LIU, Jiwen;MA, Zhihua;MEDINA, Julio C.;PATTAROPONG, Vatee;SHEN, Wang;VIMOLRATANA, Marc;WANG, Yingcai;WANG, Zhongyu;YU, Ming;ZHU, Liusheng WO2010/45258, 2010, A2 Location in patent:Page/Page column 119
99-76-3
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29415-97-2
173 suppliers
$5.00/1g
14348-41-5
173 suppliers
$8.00/1g
18107-18-1
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$33.00/5g
29415-97-2
173 suppliers
$5.00/1g
99-76-3
784 suppliers
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41727-47-3
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$23.19/10g
29415-97-2
173 suppliers
$5.00/1g