methyl 4-bromo-3,5-dimethoxybenzoate synthesis
- Product Name:methyl 4-bromo-3,5-dimethoxybenzoate
- CAS Number:26050-64-6
- Molecular formula:C10H11BrO4
- Molecular Weight:275.1
16534-12-6
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$21.21/1gm:
26050-64-6
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$5.00/1g
Yield: 92%
Reaction Conditions:
with potassium carbonate;dimethyl sulfate in acetone for 24 h;Reflux;Inert atmosphere;
Steps:
1 4.1.1 Methyl 4-bromo-3,5-dimethoxybenzoate (4)
To the stirred solution of 4-bromo-3,5-dihydroxybenzoic acid (3) 24.0 g, 0.103 mol) in dry acetone (100 mL), K2CO3 (20.0 g, 0.145 mol), and dimethyl sulfate (20 mL, 0.309 mol) was added with caution.
The reaction mixture was refluxed for 24 h.
On completion of reaction (TLC control) the reaction mixture was filtered off and the filtrate was concentrated in vacuo.
Recrystallization from ethanol afforded methyl 4-bromo-3,5-dimethoxybenzoate 4 as colorless prisms. (24.5 g, 92%) Rf=0.65; Mp 124-126 °C (lit.
References:
Saeed, Aamer;Mahesar, Parvez Ali [Tetrahedron,2014,vol. 70,# 7,p. 1401 - 1407]
67-56-1
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56518-42-4
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$14.00/1g
26050-64-6
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34126-16-4
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$55.60/2 g
74-88-4
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$15.00/10g
26050-64-6
43 suppliers
$5.00/1g
16534-12-6
216 suppliers
$21.21/1gm:
77-78-1
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$19.69/1ml
26050-64-6
43 suppliers
$5.00/1g
74-88-4
351 suppliers
$15.00/10g
26050-64-6
43 suppliers
$5.00/1g