N-Boc-4-broMo-L-phenylalanine Methyl ester synthesis
- Product Name:N-Boc-4-broMo-L-phenylalanine Methyl ester
- CAS Number:266306-18-7
- Molecular formula:C15H20BrNO4
- Molecular Weight:358.23
62129-39-9
233 suppliers
$12.50/1G
74-88-4
353 suppliers
$15.00/10g
266306-18-7
40 suppliers
$36.00/100mg
Yield:266306-18-7 96%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 3 h;Inert atmosphere;
Steps:
5 (S)-Methyl 3-(4-bromophenyl)-2-(tert-butoxycarbonylamino)propanoate (1)
Methyl iodide (25 g, 0.177 ml) and potassium carbonate (60.2 g, 0.436 ml) were added to a solution of Boc-(S)-2-amino-3-(4-bromophenyl)propanoic acid (50 g, 0.145 moi) in DMF (500 mL) under argon and the reaction mixture was stirred for 3 h at room temperature. The mixture was diluted with water (500 mL) and then extracted with EtOAc (500 mL). The organic layer was washed with brine (300 mL), dried over anhydrous sodium sulfate and concentrated to afford compound 1 (50 g, 96% yield).
References:
WO2015/32942,2015,A1 Location in patent:Page/Page column 42
24424-99-5
863 suppliers
$13.50/25G
99359-33-8
18 suppliers
inquiry
266306-18-7
40 suppliers
$36.00/100mg
589-87-7
539 suppliers
$10.00/1g
93267-04-0
258 suppliers
$5.00/250mg
266306-18-7
40 suppliers
$36.00/100mg
67-56-1
776 suppliers
$9.00/25ml
62129-39-9
233 suppliers
$12.50/1G
266306-18-7
40 suppliers
$36.00/100mg
67-56-1
776 suppliers
$9.00/25ml
24424-99-5
863 suppliers
$13.50/25G
24250-84-8
247 suppliers
$12.00/500mg
266306-18-7
40 suppliers
$36.00/100mg